Julie C Price, PhD
Director, PET Pharmacokinetic Modeling, Athinoula A. Martinos Center
jcprice@mgh.harvard.edu
617-726-7700
My area of research expertise is quantitative PET imaging methods. This includes evaluation of novel PET radiotracers using pharmacokinetic modeling, general methodology development, study design, and data analysis/interpretation. These studies have improved our understanding of normal and pathological neurophysiology in the living human for applications that include healthy brain function and aging, neurodegeneration, sleep, depression, eating disorders, brain injury and diabetes. This multidisciplinary research includes collaborations with clinical researchers across multiple disciplines, e.g., Radiology, Psychiatry, Neurology, Endocrinology, and Rehabilitation Medicine.
- 2016-… MGH & Harvard Medical School
- 1994-2016 University of Pittsburgh
Selected publications
- Baker, S. L., Lockhart, S. N., Price, J. C., He, M., Huesman, R. H., Schonhaut, D., … Jagust, W. J. (2017). Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging. J. Nucl. Med., 58(2), 332–338.
- Gunn, R. N., Slifstein, M., Searle, G. E., & Price, J. C. (2015). Quantitative imaging of protein targets in the human brain with PET. Phys Med Biol, 60(22), 363–411.
- Klunk, W. E., Koeppe, R. A., Price, J. C., Benzinger, T. L., Devous, M. D., Jagust, W. J., … Mintun, M. A. (2015). The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement, 11(1), 1–15.
- Goodpaster, B. H., Bertoldo, A., Ng, J. M., Azuma, K., Pencek, R. R., Kelley, C., … Kelley, D. E. (2014). Interactions among glucose delivery, transport, and phosphorylation that underlie skeletal muscle insulin resistance in obesity and type 2 Diabetes: studies with dynamic PET imaging. Diabetes, 63(3), 1058–1068.
- Price, J. C., Klunk, W. E., Lopresti, B. J., Lu, X., Hoge, J. A., Ziolko, S. K., … Mathis, C. A. (2005). Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J. Cereb. Blood Flow Metab., 25(11), 1528–1547.
- Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., … Langstrom, B. (2004). Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann. Neurol., 55(3), 306–319.
- Price, J. C., Mayberg, H. S., Dannals, R. F., Wilson, A. A., Ravert, H. T., Sadzot, B., … Frost, J. J. (1993). Measurement of Benzodiazepine Receptor Number and Affinity in Humans Using Tracer Kinetic Modeling, Positron Emission Tomography, and [11C]Flumazenil. Journal of Cerebral Blood Flow & Metabolism, 13(4), 656–667. https://doi.org/10.1038/jcbfm.1993.84
